{"success":true,"database":"eegdash","data":{"_id":"6953f4249276ef1ee07a340f","dataset_id":"ds005688","associated_paper_doi":null,"authors":["Henry Tan","Devon Griggs","Lucas Chen","Kahte Culevski","Kat Floerchinger","Alissa Phutirat","Gabe Koh","Nels Schimek","Pierre Mourad"],"bids_version":"1.8.0","contact_info":["Henry Tan"],"contributing_labs":null,"data_processed":false,"dataset_doi":"doi:10.18112/openneuro.ds005688.v1.0.1","datatypes":["eeg"],"demographics":{"subjects_count":20,"ages":[],"age_min":null,"age_max":null,"age_mean":null,"species":null,"sex_distribution":null,"handedness_distribution":null},"experimental_modalities":null,"external_links":{"source_url":"https://openneuro.org/datasets/ds005688","osf_url":null,"github_url":null,"paper_url":null},"funding":["R01 NS119395"],"ingestion_fingerprint":"81aaca4494204c0a558d4af24b37e90bc3cbb2f3de20ddc2ffe9e15a70616e5d","license":"CC0","n_contributing_labs":null,"name":"visStim","readme":"Dataset description\n===================\nThis dataset was collected for the study \"Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice\" by Tan et al. (2024). The research demonstrates how transcranially delivered diagnostic ultrasound (tDUS) modulates the brain's receptivity to external stimuli, using a blinking light stimulus in a mouse model.\nThe study findings highlight the potential for diagnostic ultrasound to intentionally modulate brain function, paving the way for possible future clinical and therapeutic applications.\nPlease cite the following paper when using this dataset:\nTan H, Griggs DJ, Chen L, et al. Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice. Frontiers in Neuroscience. 2024. DOI: [in peer review].\nLicense\n-------\nThis dataset is proprietary to the Department of Neurological Surgery, University of Washington, Seattle, WA, USA.\nUsage is restricted to academic and non-commercial research. Redistribution, modification, or commercial use is prohibited without prior permission.\nFor inquiries, contact: Pierre D. Mourad (doumitt@uw.edu).\nAcknowledgements\n----------------\nWe thank the Department of Neurological Surgery, University of Washington, for internal funding.\nThis research was supported by R01 NS119395 and P51 OD010425 (DJG) and the Mary Gates Research Scholarship** (HT).\nDataset Overview\n-----------------\nThis dataset comprises electrocorticography (ECoG) recordings from three cohorts of C57BL/6 mice exposed to combinations of diagnostic ultrasound (tDUS) and blinking light stimuli. The study investigates how tDUS influences the visual cortex's response to external visual stimulation.\nKey Features:\n- Subjects: 20 C57BL/6 mice divided into three experimental cohorts:\n  1. Light-only cohort: Exposed to blinking light only.\n  2. US-only cohort: Exposed to tDUS without light.\n  3. US+Light cohort: Exposed to blinking light combined with tDUS.\n- Electrode Placement: ECoG electrodes targeted visual and somatosensory cortices.\n- Recording Conditions: Data recorded at 20 kS/s, filtered (5–55 Hz), and analyzed with MATLAB.\nData Structure\n---------------\nData Files:\n- Raw ECoG Data: Continuous brain activity recordings.\n- Event-Triggered Data: Segment-specific RMS values for blinking light events.\n- Processed Data: Filtered and normalized brain activity traces.\nMetadata:\n- Experimental conditions, cohort allocation, and baseline brain activity.\nMethodology\n-----------\n- Stimulation Protocols: Mice were exposed to blinking light stimuli (10 seconds per event) and tDUS delivered through a P21x5-1 scan head (Sonosite MicroMaxx system).\n- Data Collection: Baseline and event-triggered ECoG signals were recorded using LabChart software.\n- Analysis: RMS values normalized to baseline activity for comparative statistical analysis.\nOutcomes\n________\nKey Findings:\n1. Enhanced Brain Activity: Simultaneous tDUS and blinking light increased cortical activity compared to light alone.\n2. Persistent Effects: tDUS effects on brain activity persisted after stimulation ceased.\n3. No Effect of tDUS Alone: tDUS without light did not activate cortical activity but reduced subsequent activity.\nReferences\n___________\nFor a complete list of references, please consult the manuscript.","recording_modality":["eeg"],"senior_author":"Pierre Mourad","sessions":["01"],"size_bytes":9036020603,"source":"openneuro","study_design":null,"study_domain":null,"tasks":["baseline","trial1","trial2","trial3","trial4"],"timestamps":{"digested_at":"2026-04-22T12:28:40.760272+00:00","dataset_created_at":"2024-12-02T16:12:56.962Z","dataset_modified_at":"2024-12-03T14:45:54.000Z"},"total_files":89,"storage":{"backend":"s3","base":"s3://openneuro.org/ds005688","raw_key":"dataset_description.json","dep_keys":["CHANGES","README.txt","participants.tsv"]},"tagger_meta":{"config_hash":"4a051be509a0e3d0","metadata_hash":"8d74398d3937cfae","model":"openai/gpt-5.2","tagged_at":"2026-01-20T18:35:15.756225+00:00"},"tags":{"pathology":["Healthy"],"modality":["Visual"],"type":["Clinical/Intervention"],"confidence":{"pathology":0.7,"modality":0.85,"type":0.7},"reasoning":{"few_shot_analysis":"Few-shot conventions used:\n- Modality is based on the *stimulus channel*, not recording type. E.g., the schizophrenia visual dot-motion example is labeled Visual because stimuli are visual.\n- When an explicit intervention/clinical biomarker focus is primary (e.g., Parkinson's cross-modal oddball labeled Clinical/Intervention; dementia resting dataset labeled Clinical/Intervention), the Type can be Clinical/Intervention rather than generic perception/task-mechanics.\nApplied here: the dataset repeatedly emphasizes transcranial diagnostic ultrasound (tDUS) as the manipulation/intervention while using a blinking light as an external probe, suggesting a Type closer to an intervention/neuromodulation study than purely visual perception.","metadata_analysis":"Key metadata facts (quotes):\n- Population/organism: \"electrocorticography (ECoG) recordings from ... C57BL/6 mice\" and \"Subjects: 20 C57BL/6 mice\".\n- Stimulus modality: \"using a blinking light stimulus in a mouse model\" and \"Mice were exposed to blinking light stimuli (10 seconds per event)\".\n- Intervention/manipulation: \"Diagnostic ultrasound enhances, then reduces\" and \"transcranially delivered diagnostic ultrasound (tDUS) modulates the brain's receptivity to external stimuli\"; cohorts include \"US-only\" and \"US+Light\".\n- Research aim: \"investigates how tDUS influences the visual cortex's response to external visual stimulation\".","paper_abstract_analysis":"No useful paper information. (The README cites a manuscript \"in peer review\" but no abstract text is provided beyond the README summary.)","evidence_alignment_check":"Pathology:\n- Metadata says: mice are standard strain \"C57BL/6 mice\" with no disease model described.\n- Few-shot pattern suggests: if no disorder recruitment is described, use Healthy.\n- Alignment: ALIGN.\n\nModality:\n- Metadata says: \"blinking light stimulus\" / \"blinking light stimuli\" are the external stimuli; ultrasound is a transcranial manipulation.\n- Few-shot pattern suggests: label modality by the presented stimulus channel (visual tasks -> Visual).\n- Alignment: ALIGN (Visual is dominant external sensory stimulus).\n\nType:\n- Metadata says: primary goal is neuromodulation: \"tDUS modulates the brain's receptivity to external stimuli\" and compares \"Light-only\", \"US-only\", and \"US+Light\" cohorts.\n- Few-shot pattern suggests: when an intervention/manipulation is the primary focus (even if not a patient cohort), Type can be Clinical/Intervention rather than Perception.\n- Alignment: Mostly ALIGN, but there is competition with Perception because responses are measured to a \"blinking light\" in visual cortex. Final choice favors intervention/neuromodulation framing in metadata.","decision_summary":"Top-2 candidates per category (head-to-head):\n\nPathology:\n1) Healthy (selected) — Evidence: \"20 C57BL/6 mice\" with no disease/lesion/model described; cohorts differ by stimulation condition (\"Light-only\", \"US-only\", \"US+Light\") rather than pathology.\n2) Other — Would apply if a specific animal disease model were described, but none is stated.\nAlignment status: aligns with few-shot convention of labeling non-clinical normative cohorts as Healthy.\nConfidence justification: explicit non-disease population description, but no explicit phrase like 'healthy mice'.\n\nModality:\n1) Visual (selected) — Evidence: \"blinking light stimulus\"; \"exposed to blinking light stimuli\"; study probes \"visual cortex\" responses to visual stimulation.\n2) Other — Could be argued because ultrasound is also delivered, but it is a neuromodulatory intervention rather than a sensory stimulus modality.\nAlignment status: aligns with few-shot convention (stimulus channel determines modality).\nConfidence justification: multiple explicit visual-stimulus quotes.\n\nType:\n1) Clinical/Intervention (selected) — Evidence: \"transcranially delivered diagnostic ultrasound (tDUS) modulates\"; experimental cohorts explicitly vary ultrasound exposure (\"US-only\" and \"US+Light\"); aim is how tDUS changes responsiveness.\n2) Perception — Evidence: visual stimulation and \"visual cortex's response to external visual stimulation\" could be framed as sensory processing.\nAlignment status: generally aligns with few-shot convention that intervention-centric studies map to Clinical/Intervention.\nConfidence justification: strong intervention framing but no patient/therapy trial; thus moderate confidence."}},"nemar_citation_count":0,"computed_title":"visStim","nchans_counts":[{"val":5,"count":86},{"val":1,"count":3}],"sfreq_counts":[{"val":10000.0,"count":74},{"val":20000.0,"count":15}],"stats_computed_at":"2026-04-22T23:16:00.310791+00:00","source_url":"https://openneuro.org/datasets/ds005688","total_duration_s":6234.0,"author_year":"Tan2024","canonical_name":null}}